NR0B1

Across TCGA cell cohorts, NR0B1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NR0B1-associated genes across cancer lineages are OR1L6, URAD, and LIPN. Each is linked with NR0B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NR0B1-to-partner and partner-to-NR0B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L6 grouped by NR0B1-low versus NR0B1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NR0B1→partner) and Y-score (partner→NR0B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR1L6 →	+0.035	+5.029	<.001	.006	3	1
LUNG_SCLC	URAD →	+0.044	+5.029	<.001	.006	3	1
LUNG_SCLC	LIPN →	+0.086	+5.643	<.001	.002	3	1
CNS	CST5 →	+0.113	+4.981	<.001	.008	3	1
CNS	OR4X2 →	+0.031	+4.981	<.001	.008	3	1
BLOOD_Leukemia	TEX43 →	+0.141	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

OR1L6 by NR0B1 expression — LUNG_SCLC

Explore this box plot interactively →