NPY5R

Across TCGA pan-cancer cohorts, NPY5R RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of NPY5R’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NPY5R RNA is repressed in tumor relative to normal tissue. In most cancer types NPY5R is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and THCA are the cancer types where NPY5R tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NPY5R RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.714	<.001	12	view →
KICH	Female	II,III,IV	−2.412	<.001	11	view →
THCA	Male	IV	−0.850	<.001	11	view →
COAD	Female	II,III,IV	−0.297	<.001	10	view →
BRCA	All	III,IV	−1.812	<.001	8	view →
LUSC	All	II,III,IV	−0.260	<.001	8	view →
HNSC	All	II,III,IV	−0.228	<.001	8	view →
LUAD	Female	III,IV	−0.408	<.001	7	view →
KIRP	Male	All	−1.031	<.001	6	view →
UCEC	All	All	−0.726	<.001	6	view →
STAD	All	II,III,IV	−0.144	.003	6	view →
READ	All	All	−0.291	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

NPY5R–KIRC

Open the KIRC breakdown →