Across TCGA pan-cancer cohorts, NPY4R RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of NPY4R’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NPY4R RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NPY4R is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.
KIRC, HNSC, and LUSC are the cancer types where NPY4R tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NPY4R RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.