NPY1R

Across TCGA patient cohorts, NPY1R mutation is significantly associated with the RNA expression of many other genes, with 3,414 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible NPY1R-associated genes across cancer lineages are HAUS2, XRCC6, and RTCB. Each is linked with NPY1R in more than 3 cancer types. Because this analysis shows association rather than direction, both NPY1R-to-partner and partner-to-NPY1R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HAUS2 grouped by NPY1R-low versus NPY1R-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPY1R→partner) and Y-score (partner→NPY1R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HAUS2 →	+0.558	+2.553	<.001	<.001	3	4
UCEC	XRCC6 →	+0.436	+2.469	.001	.001	3	3
UCEC	RTCB →	+0.446	+2.961	.002	<.001	3	3
UCEC	EIF2B2 →	+0.323	+1.617	.003	.006	2	4
SKCM	ATP6V1E1 →	+0.408	+1.328	<.001	.008	3	3
UCEC	EIF2S1 →	+0.473	+1.797	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,414 associations by consensus.

HAUS2 by NPY1R expression — SKCM

Explore this box plot interactively →