NPY1R

Across TCGA patient cohorts, NPY1R mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPY1R-associated genes across cancer lineages are eEF2, TIGAR, and STAT3_pY705. Each is linked with NPY1R in more than 1 cancer types. Because this analysis shows association rather than direction, both NPY1R-to-partner and partner-to-NPY1R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by NPY1R-low versus NPY1R-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPY1R→partner) and Y-score (partner→NPY1R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.349	+2.459	.006	.018	3	2
UCEC	TIGAR →	+0.134	+1.611	.015	.011	3	2
SKCM	STAT3_pY705 →	-0.251	-1.584	.009	.018	3	2
SKCM	c-Kit →	-0.466	-1.584	.047	.018	3	2
UCEC	eIF4E →	+0.155	+2.321	.041	.001	3	1
UCEC	JNK2 →	+0.203	+1.584	.004	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

eEF2 by NPY1R expression — UCEC

Explore this box plot interactively →