NPY1R

Across TCGA cell cohorts, NPY1R mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible NPY1R-associated genes across cancer lineages are PRAMEF10, PRAMEF20, and PRAMEF17. Each is linked with NPY1R in more than 1 cancer types. Because this analysis shows association rather than direction, both NPY1R-to-partner and partner-to-NPY1R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF10 grouped by NPY1R-low versus NPY1R-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPY1R→partner) and Y-score (partner→NPY1R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PRAMEF10 →	+0.885	+4.643	<.001	.004	3	1
LUNG_SCLC	PRAMEF20 →	+0.367	+4.269	<.001	.005	3	1
LUNG_SCLC	PRAMEF17 →	+0.010	+4.643	<.001	.004	3	1
LUNG_SCLC	RBMY1J →	+0.701	+4.523	<.001	.003	3	1
LARGE_INTESTINE	GKN1 →	+0.063	+4.095	<.001	.009	3	1
LARGE_INTESTINE	SLC15A5 →	+0.017	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

PRAMEF10 by NPY1R expression — LUNG_SCLC

Explore this box plot interactively →