NPY

Across TCGA pan-cancer cohorts, NPY RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated NPY data layer compared with 1 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher NPY RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NPY expression acts as an unfavorable survival marker, although some lineages such as LUSC and PAAD show a favorable association.

UCEC, OV, and HNSC are the cancer types where NPY RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	All	0.479	0.688	<.001	90	view →
OV	DFS	Quartile	All	0.482	0.601	.004	54	view →
HNSC	OS	Quartile	All	0.682	0.770	.001	28	view →
LUSC	OS	Median	All	0.940	0.693	<.001	23	view →
PAAD	OS	Tertile	II,III,IV	0.611	0.310	.010	21	view →
UCS	DFS	Quartile	III,IV	0.610	0.246	.009	20	view →
UVM	DFS	Tertile	All	0.460	0.857	.008	18	view →
ESCA	OS	Quartile	III,IV	0.632	0.317	.015	14	view →
CESC	OS	Tertile	IV	0.680	0.194	.033	12	view →
TGCT	DFS	Quartile	All	0.516	0.852	.011	12	view →
READ	DFS	Tertile	II,III,IV	0.244	0.824	.012	12	view →
KIRP	OS	Quartile	All	0.876	0.631	.014	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

NPY–UCEC (DFS)

Open the UCEC breakdown →