NPY

Across TCGA pan-cancer cohorts, NPY mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NPY data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NPY mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NPY expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, LUAD, and PDAC are the cancer types where NPY mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	1.000	0.854	.020	32	view →
LUAD	DFS	Tertile	III,IV	0.549	0.968	.020	7	view →
PDAC	OS	Quartile	III,IV	0.930	0.629	.045	1	view →
GBM	DFS	Quartile	All	0.872	0.583	.011	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NPY–CCRCC (DFS)

Open the CCRCC breakdown →