NPVF

Across TCGA cell cohorts, NPVF mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NPVF-associated genes across cancer lineages are TTLL8 and PPEF2. Each is linked with NPVF in more than 1 cancer types. Because this analysis shows association rather than direction, both NPVF-to-partner and partner-to-NPVF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTLL8 grouped by NPVF-low versus NPVF-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPVF→partner) and Y-score (partner→NPVF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TTLL8 →	+0.004	+4.437	<.001	.004	3	1
LARGE_INTESTINE	PPEF2 →	+0.050	+3.736	<.001	.007	2	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

TTLL8 by NPVF expression — LARGE_INTESTINE

Explore this box plot interactively →