Across TCGA patient cohorts, NPTXR mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPTXR-associated genes across cancer lineages are PCNA, C-Raf, and eIF4E. Each is linked with NPTXR in more than 1 cancer types. Because this analysis shows association rather than direction, both NPTXR-to-partner and partner-to-NPTXR results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPTXR→partner) and Y-score (partner→NPTXR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.218	+2.584	.007	.010	3	2
UCEC	C-Raf →	+0.129	+2.115	.016	.017	3	2
UCEC	eIF4E →	+0.169	+3.335	.032	.005	3	1
UCEC	ER-alpha_pS118 →	-0.352	-1.700	.008	.042	3	1
UCEC	HER2_pY1248 →	-0.202	-2.662	.044	<.001	3	1
UCEC	IGFBP2 →	-0.624	-1.415	.010	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

NPTXR survival (RNA) · tumor vs normal (RNA) · all NPTXR data types