Across TCGA cell cohorts, NPTXR mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible NPTXR-associated genes across cancer lineages are GALP, KRTAP4-6, and HTR2A. Each is linked with NPTXR in more than 1 cancer types. Because this analysis shows association rather than direction, both NPTXR-to-partner and partner-to-NPTXR results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPTXR→partner) and Y-score (partner→NPTXR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GALP →	+0.017	+4.415	<.001	.007	3	1
SKIN	KRTAP4-6 →	+0.034	+4.415	<.001	.007	3	1
LUNG_NSCLC_LUAD	HTR2A →	+0.752	+4.093	.001	.004	3	1
LUNG_NSCLC_LUAD	NEUROG3 →	+0.062	+4.215	<.001	.002	3	1
LUNG_NSCLC_LUAD	LRIT1 →	+0.035	+3.947	<.001	.004	3	1
LUNG_NSCLC_LUAD	TCF23 →	+0.019	+5.149	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

NPTXR survival (RNA) · tumor vs normal (RNA) · all NPTXR data types