NPTN

Across TCGA pan-cancer cohorts, NPTN Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NPTN data layer compared with 26 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher NPTN Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated NPTN expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

UCEC, SARC, and CHOL are the cancer types where NPTN Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.435	.008	36	view →
SARC	DFS	Median	All	0.069	0.632	<.001	12	view →
CHOL	OS	Median	All	0.089	0.727	.001	9	view →
READ	OS	Median	II,III,IV	0.527	0.933	<.001	9	view →
STAD	DFS	Median	III,IV	1.000	0.337	.041	8	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NPTN–UCEC (DFS)

Open the UCEC breakdown →