NPTN

Across TCGA pan-cancer cohorts, NPTN mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NPTN data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NPTN mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NPTN expression acts as an unfavorable survival marker, although some lineages such as OV and GBM show a favorable association.

CCRCC, LUAD, and HNSC are the cancer types where NPTN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.596	0.942	<.001	68	view →
LUAD	DFS	Tertile	II,III,IV	0.167	0.836	.003	11	view →
HNSC	DFS	Quartile	All	0.271	0.810	.026	5	view →
OV	DFS	Median	All	1.000	0.864	.035	4	view →
PDAC	DFS	Tertile	III,IV	0.347	0.715	.032	4	view →
GBM	DFS	Median	All	0.816	0.684	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NPTN–CCRCC (DFS)

Open the CCRCC breakdown →