NPTN

Across TCGA pan-cancer cohorts, NPTN mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of NPTN’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where NPTN mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types NPTN is over-expressed in tumor, although a few such as COAD and OV show the opposite, repressed pattern.

COAD, HNSC, and CCRCC are the cancer types where NPTN tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NPTN mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	−1.350	<.001	11	view →
HNSC	Male	All	+0.274	<.001	8	view →
CCRCC	Male	III,IV	+0.234	<.001	8	view →
OV	All	All	−0.520	.007	2	view →
LSCC	All	All	+0.091	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

NPTN–COAD

Open the COAD breakdown →