NPTN

Across TCGA patient cohorts, NPTN protein abundance is significantly associated with the RNA expression of many other genes, with 13,247 significant associations in total. GBM shows the largest number of these associations.

The most reproducible NPTN-associated genes across cancer lineages are FEM1B, RAB11A, and INTS14. Each is linked with NPTN in more than 4 cancer types. Because this analysis shows association rather than direction, both NPTN-to-partner and partner-to-NPTN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NPTN versus FEM1B in BRCA, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPTN→partner) and Y-score (partner→NPTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FEM1B →	+0.618	+0.302	<.001	.005	3	5
OV	RAB11A →	+0.435	+0.335	.004	.003	3	4
OV	INTS14 →	+0.399	+0.396	.005	.001	3	4
LSCC	RAB6B →	+1.364	+0.327	<.001	<.001	3	4
HNSC	FCRL3 →	-0.755	-0.246	.002	<.001	3	4
LSCC	COPS2 →	+0.483	+0.251	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,247 associations by consensus.

NPTN vs FEM1B — BRCA

Explore this scatter interactively →