NPTN

Across TCGA patient cohorts, NPTN mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPTN-associated genes across cancer lineages are FoxM1, FOXO3a_pS318_S321, and JNK2. Each is linked with NPTN in more than 1 cancer types. Because this analysis shows association rather than direction, both NPTN-to-partner and partner-to-NPTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by NPTN-low versus NPTN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPTN→partner) and Y-score (partner→NPTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.204	+2.169	.035	.003	3	2
UCEC	FOXO3a_pS318_S321 →	-0.134	-2.212	.004	.010	3	2
UCEC	JNK2 →	+0.270	+2.662	<.001	<.001	3	2
UCEC	MEK1 →	+0.327	+1.765	.017	.014	3	2
UCEC	Annexin-1 →	+0.653	+2.479	<.001	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.553	+1.604	.012	.041	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

FoxM1 by NPTN expression — UCEC

Explore this box plot interactively →