Across TCGA patient cohorts, NPSR1 mutation is significantly associated with the RNA expression of many other genes, with 3,598 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPSR1-associated genes across cancer lineages are ALDOA, STIP1, and PVR. Each is linked with NPSR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NPSR1-to-partner and partner-to-NPSR1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPSR1→partner) and Y-score (partner→NPSR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ALDOA →	+0.388	+2.807	.005	.003	3	3
UCEC	STIP1 →	+0.475	+2.272	<.001	.001	3	3
UCEC	PVR →	+0.630	+3.938	<.001	<.001	3	3
UCEC	ENO1 →	+0.415	+1.942	.008	.002	3	3
UCEC	AHSA1 →	+0.340	+2.566	.001	<.001	3	3
UCEC	EIF2B2 →	+0.423	+2.212	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,598 associations by consensus.

Exploration

NPSR1 survival (RNA) · tumor vs normal (RNA) · all NPSR1 data types