NPSR1

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, NPSR1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPSR1-associated genes across cancer lineages are eEF2, EGFR_pY1068, and eIF4E. Each is linked with NPSR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPSR1-to-partner and partner-to-NPSR1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPSR1→partner) and Y-score (partner→NPSR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECeEF2 →+0.323+2.459.009.01832
UCECEGFR_pY1068 →-0.215-2.070.013.00132
UCECeIF4E →+0.200+2.070.006.00132
UCECERK2 →+0.146+1.584.029.03432
UCECINPP4B →-0.309-2.321.005.00532
UCECMEK1 →+0.427+2.584<.001.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Exploration