Across TCGA cell cohorts, NPSR1 mutation is significantly associated with the RNA expression of many other genes, with 70 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible NPSR1-associated genes across cancer lineages are CT45A2, H2BC1, and H2AC1. Each is linked with NPSR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPSR1-to-partner and partner-to-NPSR1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPSR1→partner) and Y-score (partner→NPSR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CT45A2 →	+1.177	+4.832	<.001	<.001	3	2
SOFT_TISSUE	H2BC1 →	+0.260	+4.392	<.001	.004	3	1
SOFT_TISSUE	H2AC1 →	+0.115	+4.392	<.001	.004	3	1
SOFT_TISSUE	OR13D1 →	+0.020	+4.392	<.001	.004	3	1
SOFT_TISSUE	KLRC4 →	+1.087	+3.736	<.001	.008	3	1
SOFT_TISSUE	GAGE1 →	+1.680	+3.999	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

Exploration

NPSR1 survival (RNA) · tumor vs normal (RNA) · all NPSR1 data types