NPR3

Across TCGA pan-cancer cohorts, NPR3 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated NPR3 data layer compared with 26 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher NPR3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NPR3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

BRCA, UCEC, and MESO are the cancer types where NPR3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.287	0.924	<.001	36	view →
UCEC	DFS	Median	II,III,IV	1.000	0.428	.003	30	view →
MESO	DFS	Median	III,IV	0.078	0.376	.012	9	view →
ESCA	DFS	Median	II,III,IV	0.239	0.506	.021	9	view →
ACC	OS	Median	All	0.177	0.632	.021	7	view →
STAD	OS	Median	III,IV	1.000	0.358	.024	7	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
LGG	DFS	Median	All	0.110	0.826	<.001	3	view →
LUSC	DFS	Median	All	0.064	0.791	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

NPR3–BRCA (OS)

Open the BRCA breakdown →