NPR3

Across TCGA pan-cancer cohorts, NPR3 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated NPR3 data layer compared with 26 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NPR3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NPR3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where NPR3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	All	0.969	0.747	.005	19	view →
PDAC	DFS	Quartile	II,III,IV	0.576	0.947	.004	6	view →
LUAD	OS	Median	III,IV	0.325	0.832	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

NPR3–CCRCC (OS)

Open the CCRCC breakdown →