NPR3

Across TCGA patient cohorts, NPR3 mutation is significantly associated with the RNA expression of many other genes, with 4,794 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPR3-associated genes across cancer lineages are KNSTRN, MED18, and ABHD3. Each is linked with NPR3 in more than 2 cancer types. Because this analysis shows association rather than direction, both NPR3-to-partner and partner-to-NPR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KNSTRN grouped by NPR3-low versus NPR3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPR3→partner) and Y-score (partner→NPR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	KNSTRN →	+0.398	+2.720	.007	.003	3	3
UCEC	MED18 →	+0.464	+1.975	<.001	<.001	3	3
COAD	ABHD3 →	+0.447	+2.515	.007	.001	3	3
UCEC	LSM3 →	+0.568	+1.954	<.001	<.001	3	3
COAD	ZNF584 →	+0.292	+2.242	.006	.005	3	3
COAD	SLC15A1 →	-0.871	-2.502	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,794 associations by consensus.

KNSTRN by NPR3 expression — COAD

Explore this box plot interactively →