NPR3

Across TCGA patient cohorts, NPR3 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPR3-associated genes across cancer lineages are ATM, RAD51, and eEF2. Each is linked with NPR3 in more than 4 cancer types. Because this analysis shows association rather than direction, both NPR3-to-partner and partner-to-NPR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by NPR3-low versus NPR3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPR3→partner) and Y-score (partner→NPR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.456	-1.986	<.001	.008	3	5
UCEC	RAD51 →	+0.118	+1.362	.004	.034	3	3
UCEC	eEF2 →	+0.253	+1.906	.017	.014	3	2
UCEC	eIF4E →	+0.149	+1.925	.017	.004	3	2
UCEC	mTOR_pS2448 →	-0.103	-1.584	.020	.002	3	2
UCEC	PCNA →	+0.195	+1.736	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

ATM by NPR3 expression — UCEC

Explore this box plot interactively →