NPR3

Across TCGA cell cohorts, NPR3 mutation is significantly associated with the RNA expression of many other genes, with 120 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NPR3-associated genes across cancer lineages are TM2D3, GPR31, and KCNA5. Each is linked with NPR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPR3-to-partner and partner-to-NPR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TM2D3 grouped by NPR3-low versus NPR3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPR3→partner) and Y-score (partner→NPR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TM2D3 →	+0.525	+3.212	.001	.006	3	2
OESOPHAGUS	GPR31 →	+0.016	+4.906	<.001	.006	3	1
OESOPHAGUS	KCNA5 →	+0.013	+4.906	<.001	.006	3	1
OESOPHAGUS	SPHKAP →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	CCL13 →	+0.049	+4.906	<.001	.006	3	1
BLOOD_Lymphoma	SRRM4 →	+0.030	+4.523	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 120 associations by consensus.

TM2D3 by NPR3 expression — LARGE_INTESTINE

Explore this box plot interactively →