NPR1

Across TCGA pan-cancer cohorts, NPR1 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated NPR1 data layer compared with 27 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NPR1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated NPR1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

HNSC, UCEC, and BRCA are the cancer types where NPR1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.074	0.712	<.001	32	view →
UCEC	DFS	Median	All	0.964	0.626	.018	24	view →
BRCA	OS	Median	III,IV	0.027	0.907	<.001	16	view →
READ	DFS	Median	All	0.182	0.798	.010	12	view →
LIHC	DFS	Median	All	0.083	0.555	<.001	12	view →
UCS	DFS	Median	All	0.136	0.523	.034	6	view →
GBM	OS	Median	All	0.104	0.415	.024	6	view →
KIRP	OS	Median	All	0.192	0.705	.015	4	view →
MESO	OS	Median	II,III,IV	0.180	0.560	.046	3	view →
SKCM	DFS	Median	II,III,IV	0.291	0.711	.028	3	view →
STAD	DFS	Median	III,IV	1.000	0.318	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

NPR1–HNSC (DFS)

Open the HNSC breakdown →