NPR1

Across TCGA patient cohorts, NPR1 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,459 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NPR1-associated proteins across cancer lineages are MMRN2, COL14A1, and AOC3. Each is linked with NPR1 in more than 8 cancer types. Because this analysis shows association rather than direction, both NPR1-to-partner and partner-to-NPR1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NPR1 versus MMRN2 in GBM, with a Pearson correlation of 0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NPR1→partner) and Y-score (partner→NPR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MMRN2 →	+0.631	+0.746	<.001	<.001	3	9
GBM	COL14A1 →	+0.714	+0.486	.001	.005	3	8
BRCA	AOC3 →	+0.699	+0.734	<.001	<.001	3	8
CCRCC	VWF →	+0.450	+0.781	.003	.006	2	9
GBM	RASIP1 →	+0.385	+0.743	<.001	<.001	3	7
BRCA	CD34 →	+0.915	+1.007	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,459 associations by consensus.

NPR1 vs MMRN2 — GBM

Explore this scatter interactively →