NPR1

Across TCGA patient cohorts, NPR1 mutation is significantly associated with the RNA expression of many other genes, with 1,943 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPR1-associated genes across cancer lineages are ARHGEF38-IT1, KLRD1, and RNU6-1169P. Each is linked with NPR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NPR1-to-partner and partner-to-NPR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARHGEF38-IT1 grouped by NPR1-low versus NPR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPR1→partner) and Y-score (partner→NPR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ARHGEF38-IT1 →	+0.575	+2.158	<.001	<.001	3	3
LUSC	KLRD1 →	+0.428	+2.257	<.001	.006	3	3
SKCM	RNU6-1169P →	+0.103	+2.099	<.001	.007	3	3
SKCM	ARSDP1 →	+0.213	+1.494	<.001	.005	3	3
READ	OR2U1P →	+0.066	+4.672	<.001	.004	3	2
READ	RAB9BP1 →	+0.099	+5.096	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,943 associations by consensus.

ARHGEF38-IT1 by NPR1 expression — UCEC

Explore this box plot interactively →