NPR1

Across TCGA patient cohorts, NPR1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPR1-associated genes across cancer lineages are 4E-BP1_pT70, Acetyl-a-Tubulin-Lys40, and Rad50. Each is linked with NPR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NPR1-to-partner and partner-to-NPR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pT70 grouped by NPR1-low versus NPR1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPR1→partner) and Y-score (partner→NPR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	4E-BP1_pT70 →	+0.189	+3.000	.001	.035	3	3
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.493	+1.925	.007	.005	3	3
UCEC	Rad50 →	-0.178	-2.459	.041	.019	3	3
COAD	MSH2 →	-0.285	-3.161	.009	.019	3	2
UCEC	INPP4B →	-0.335	-2.222	.004	.009	3	2
UCEC	Notch1 →	+0.130	+2.335	.010	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

4E-BP1_pT70 by NPR1 expression — COAD

Explore this box plot interactively →