NPR1

Across TCGA cell cohorts, NPR1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,804 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible NPR1-associated GO terms across cancer lineages are Chylomicron remnant clearance, Triglyceride-rich lipoprotein particle clearance, and Low-density lipoprotein particle remodeling. Each is linked with NPR1 in more than 7 cancer types. Because this analysis shows association rather than direction, both NPR1-to-partner and partner-to-NPR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chylomicron remnant clearance grouped by NPR1-low versus NPR1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NPR1→partner) and Y-score (partner→NPR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Chylomicron remnant clearance →	+1.231	+0.601	<.001	<.001	3	8
OESOPHAGUS	Triglyceride-rich lipoprotein particle clearance →	+1.231	+0.601	<.001	<.001	3	8
OESOPHAGUS	Low-density lipoprotein particle remodeling →	+1.414	+0.633	<.001	<.001	3	7
OESOPHAGUS	Negative regulation of potassium ion export across plasma membrane →	-0.166	-0.665	.001	.006	3	7
STOMACH	Negative regulation of dopamine receptor signaling pathway →	+1.210	+0.653	<.001	<.001	3	6
OVARY	Cardiac muscle cell action potential involved in contraction →	-0.076	-1.595	.004	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,804 associations by consensus.

Chylomicron remnant clearance by NPR1 expression — OESOPHAGUS

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