NPR1

Across TCGA cell cohorts, NPR1 mutation is significantly associated with the RNA expression of many other genes, with 168 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NPR1-associated genes across cancer lineages are DPPA2, SIGLEC7, and PGLYRP4. Each is linked with NPR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPR1-to-partner and partner-to-NPR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPPA2 grouped by NPR1-low versus NPR1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPR1→partner) and Y-score (partner→NPR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DPPA2 →	+1.311	+4.032	.004	.001	3	2
LUNG_SCLC	SIGLEC7 →	+0.411	+2.869	.006	.008	3	2
SOFT_TISSUE	PGLYRP4 →	+0.012	+4.369	<.001	.008	3	1
SOFT_TISSUE	BHLHA9 →	+0.027	+4.977	<.001	.002	3	1
LUNG_SCLC	AADAC →	+0.627	+3.617	<.001	.004	3	1
LUNG_SCLC	CAPSL →	+0.708	+3.263	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 168 associations by consensus.

DPPA2 by NPR1 expression — LUNG_SCLC

Explore this box plot interactively →