NPPA

Across TCGA patient cohorts, NPPA mutation is significantly associated with the RNA expression of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPPA-associated genes across cancer lineages are RN7SL422P, MIR6823, and ZNF705D. Each is linked with NPPA in more than 1 cancer types. Because this analysis shows association rather than direction, both NPPA-to-partner and partner-to-NPPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL422P grouped by NPPA-low versus NPPA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPPA→partner) and Y-score (partner→NPPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL422P →	+0.105	+5.736	<.001	.001	3	2
UCEC	MIR6823 →	+0.342	+4.226	.001	.008	3	2
SKCM	ZNF705D →	+0.007	+4.469	.001	.006	3	2
UCEC	IGKV2OR2-2 →	+0.301	+3.759	<.001	.005	3	1
UCEC	MIR6859-2 →	+0.780	+4.105	<.001	.001	3	1
UCEC	ANKRD20A3P →	+0.004	+4.551	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

RN7SL422P by NPPA expression — UCEC

Explore this box plot interactively →