NPNT

Across TCGA pan-cancer cohorts, NPNT mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NPNT data layer compared with 20 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NPNT mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NPNT expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, LUAD, and UCEC are the cancer types where NPNT mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	All	0.973	0.737	<.001	73	view →
LUAD	DFS	Quartile	II,III,IV	0.362	0.869	<.001	60	view →
UCEC	DFS	Median	All	0.936	1.000	.023	6	view →
PDAC	OS	Median	IV	0.395	0.937	.026	3	view →
HNSC	DFS	Median	III,IV	0.988	0.916	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NPNT–CCRCC (OS)

Open the CCRCC breakdown →