NPNT

Across TCGA patient cohorts, NPNT protein abundance is significantly associated with the RNA expression of many other genes, with 9,662 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible NPNT-associated genes across cancer lineages are TBX2, ASPA, and C1orf21. Each is linked with NPNT in more than 4 cancer types. Because this analysis shows association rather than direction, both NPNT-to-partner and partner-to-NPNT results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NPNT versus TBX2 in CCRCC, with a Pearson correlation of 0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPNT→partner) and Y-score (partner→NPNT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TBX2 →	+0.760	+0.277	<.001	.008	3	5
OV	ASPA →	+0.458	+0.801	.004	.003	3	4
BRCA	C1orf21 →	+0.995	+0.699	.001	<.001	3	4
HNSC	MEIS2 →	+0.611	+0.406	.001	.008	3	4
BRCA	TBX3 →	+1.294	+0.648	.001	.003	3	4
BRCA	PDE5A →	+1.076	+0.712	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,662 associations by consensus.

NPNT vs TBX2 — CCRCC

Explore this scatter interactively →