NPNT

Across TCGA patient cohorts, NPNT mutation is significantly associated with the RNA expression of many other genes, with 3,728 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPNT-associated genes across cancer lineages are BTG3, RBBP4, and SLBP. Each is linked with NPNT in more than 2 cancer types. Because this analysis shows association rather than direction, both NPNT-to-partner and partner-to-NPNT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BTG3 grouped by NPNT-low versus NPNT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPNT→partner) and Y-score (partner→NPNT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BTG3 →	+0.463	+1.716	.005	.004	3	3
UCEC	RBBP4 →	+0.453	+1.726	.002	.002	3	3
UCEC	SLBP →	+0.606	+2.332	<.001	<.001	3	3
UCEC	CCDC51 →	+0.379	+2.000	.007	.001	3	3
UCEC	YTHDF3-AS1 →	+0.446	+1.513	.003	.007	3	3
UCEC	PHF5A →	+0.517	+2.700	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,728 associations by consensus.

BTG3 by NPNT expression — UCEC

Explore this box plot interactively →