NPNT

Across TCGA patient cohorts, NPNT mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPNT-associated genes across cancer lineages are MEK1, 4E-BP1_pT37_T46, and Caspase-7-cleavedD198. Each is linked with NPNT in more than 1 cancer types. Because this analysis shows association rather than direction, both NPNT-to-partner and partner-to-NPNT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by NPNT-low versus NPNT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPNT→partner) and Y-score (partner→NPNT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.458	+2.662	<.001	<.001	3	2
UCEC	4E-BP1_pT37_T46 →	-0.389	-1.861	.005	.049	3	2
UCEC	Caspase-7-cleavedD198 →	+0.482	+2.135	.030	.010	3	2
UCEC	Chk2_pT68 →	-0.150	-3.143	.031	.018	3	2
UCEC	Di-Ras3 →	-0.118	-3.446	.034	.005	3	2
SKCM	Transglutaminase →	+0.180	+2.000	.023	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

MEK1 by NPNT expression — UCEC

Explore this box plot interactively →