NPNT

Across TCGA cell cohorts, NPNT mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible NPNT-associated genes across cancer lineages are CFC1B, KRTAP6-1, and OR13C3. Each is linked with NPNT in more than 1 cancer types. Because this analysis shows association rather than direction, both NPNT-to-partner and partner-to-NPNT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFC1B grouped by NPNT-low versus NPNT-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPNT→partner) and Y-score (partner→NPNT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CFC1B →	+0.035	+4.022	<.001	.006	3	1
SKIN	KRTAP6-1 →	+0.050	+4.022	<.001	.006	3	1
SKIN	OR13C3 →	+0.015	+4.022	<.001	.006	3	1
SKIN	ZNF99 →	+0.039	+3.688	<.001	.002	3	1
SKIN	DCAF8L1 →	+0.288	+3.823	<.001	.006	3	1
SKIN	SLC13A2 →	+0.011	+3.688	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

CFC1B by NPNT expression — SKIN

Explore this box plot interactively →