NPM3

Across TCGA pan-cancer cohorts, NPM3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NPM3 data layer compared with 29 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NPM3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NPM3 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

HNSC, LSCC, and GBM are the cancer types where NPM3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.671	0.923	.001	48	view →
LSCC	DFS	Median	II,III,IV	0.800	0.569	.023	10	view →
GBM	DFS	Median	All	0.503	0.234	.003	9	view →
PDAC	OS	Quartile	III,IV	0.182	0.662	.035	7	view →
LUAD	DFS	Quartile	III,IV	0.899	0.324	.035	4	view →
CCRCC	OS	Tertile	All	0.656	1.000	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NPM3–HNSC (DFS)

Open the HNSC breakdown →