NPM3

Across TCGA patient cohorts, NPM3 protein abundance is significantly associated with the RNA expression of many other genes, with 13,914 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NPM3-associated genes across cancer lineages are RPS10, DKC1, and SLC46A3. Each is linked with NPM3 in more than 5 cancer types. Because this analysis shows association rather than direction, both NPM3-to-partner and partner-to-NPM3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NPM3 versus RPS10 in LSCC, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPM3→partner) and Y-score (partner→NPM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RPS10 →	+0.557	+0.410	<.001	<.001	3	6
BRCA	DKC1 →	+0.576	+0.436	<.001	<.001	3	6
UCEC	SLC46A3 →	-0.777	-0.549	<.001	<.001	3	5
LSCC	ATAD2 →	+0.562	+0.336	.004	.003	3	5
OV	SNHG4 →	+1.032	+0.342	.001	.009	2	6
LSCC	TWNK →	+0.686	+0.476	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,914 associations by consensus.

NPM3 vs RPS10 — LSCC

Explore this scatter interactively →