NPM3

Across TCGA cell cohorts, NPM3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,620 significant associations in total. CNS shows the largest number of these associations.

The most reproducible NPM3-associated GO terms across cancer lineages are Nuclear receptor-mediated signaling pathway, Pseudouridine synthesis, and 'de novo' IMP biosynthetic process. Each is linked with NPM3 in more than 15 cancer types. Because this analysis shows association rather than direction, both NPM3-to-partner and partner-to-NPM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear receptor-mediated signaling pathway grouped by NPM3-low versus NPM3-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NPM3→partner) and Y-score (partner→NPM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Nuclear receptor-mediated signaling pathway →	-0.091	-1.426	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Pseudouridine synthesis →	+0.092	+1.062	<.001	<.001	3	16
SOFT_TISSUE	'de novo' IMP biosynthetic process →	+0.155	+1.324	<.001	<.001	3	15
BONE	tRNA metabolic process →	+0.092	+1.054	<.001	<.001	3	15
BONE	Positive regulation of mitochondrial RNA catabolic process →	+0.127	+0.823	<.001	.003	3	15
STOMACH	Macroautophagy →	-0.082	-1.307	.002	.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,620 associations by consensus.

Nuclear receptor-mediated signaling pathway by NPM3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →