NPM2

Across TCGA cell cohorts, NPM2 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NPM2-associated genes across cancer lineages are AVP, MMD2, and OR10H5. Each is linked with NPM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPM2-to-partner and partner-to-NPM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by NPM2-low versus NPM2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPM2→partner) and Y-score (partner→NPM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	AVP →	+0.038	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	MMD2 →	+0.036	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	OR10H5 →	+0.112	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	RNASE9 →	+0.022	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	PRR20B →	+0.159	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	PRR20A →	+0.159	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

AVP by NPM2 expression — BLOOD_Lymphoma

Explore this box plot interactively →