NPM1P43

Across TCGA pan-cancer cohorts, NPM1P43 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated NPM1P43 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher NPM1P43 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NPM1P43 expression acts as an unfavorable survival marker, although some lineages such as PAAD and LIHC show a favorable association.

SKCM, PAAD, and THYM are the cancer types where NPM1P43 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Tertile	III,IV	0.245	0.499	.006	38	view →
PAAD	OS	Tertile	II,III,IV	0.760	0.377	.013	27	view →
THYM	OS	Quartile	All	0.630	0.948	.003	22	view →
CESC	OS	Tertile	IV	0.087	0.445	.025	18	view →
LIHC	OS	Tertile	II,III,IV	1.000	0.367	.004	15	view →
KIRP	OS	Quartile	All	0.469	0.730	.028	14	view →
HNSC	OS	Quartile	III,IV	0.549	0.331	.012	10	view →
THCA	OS	Quartile	All	0.980	0.992	.003	10	view →
PCPG	OS	Tertile	All	0.933	1.000	.025	9	view →
CHOL	DFS	Quartile	III,IV	0.031	0.406	.008	9	view →
READ	OS	Tertile	III,IV	0.389	0.859	.012	9	view →
KIRC	DFS	Quartile	All	0.529	0.689	.003	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

NPM1P43–SKCM (OS)

Open the SKCM breakdown →