NPM1P21

Across TCGA pan-cancer cohorts, NPM1P21 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of NPM1P21’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NPM1P21 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NPM1P21 is over-expressed in tumor.

KIRC, HNSC, and COAD are the cancer types where NPM1P21 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NPM1P21 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	+0.274	<.001	9	view →
HNSC	All	All	+0.480	<.001	8	view →
COAD	All	II,III,IV	+0.237	.003	7	view →
KIRP	All	All	+0.143	.003	7	view →
LUSC	Male	All	+0.348	<.001	4	view →
LUAD	All	All	+0.247	<.001	4	view →
LIHC	All	II,III,IV	+0.104	.012	3	view →
PRAD	All	All	+0.194	<.001	2	view →
STAD	All	IV	+0.306	.004	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

NPM1P21–KIRC

Open the KIRC breakdown →