Across TCGA pan-cancer cohorts, NPM1P20 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of NPM1P20’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where NPM1P20 RNA is repressed in tumor relative to normal tissue. In most cancer types NPM1P20 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
THCA and KIRC are the cancer types where NPM1P20 tumor–normal differential expression is most reproducible.