NPM1

Across TCGA pan-cancer cohorts, NPM1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NPM1 data layer compared with 30 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NPM1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NPM1 expression acts as an unfavorable survival marker, although some lineages such as GBM and PDAC show a favorable association.

CCRCC, GBM, and HNSC are the cancer types where NPM1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	All	0.570	0.958	<.001	42	view →
GBM	DFS	Median	All	0.410	0.234	.036	2	view →
HNSC	DFS	Quartile	All	0.496	0.706	.032	2	view →
PDAC	DFS	Tertile	II,III,IV	0.473	0.272	.035	2	view →
LUAD	OS	Median	All	0.870	0.608	.017	2	view →
LSCC	DFS	Median	II,III,IV	1.000	0.571	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NPM1–CCRCC (DFS)

Open the CCRCC breakdown →