NPM1

Across TCGA patient cohorts, NPM1 mutation is significantly associated with the RNA expression of many other genes, with 295 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPM1-associated genes across cancer lineages are EEF1A1P39, RN7SL557P, and CSN1S2AP. Each is linked with NPM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPM1-to-partner and partner-to-NPM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EEF1A1P39 grouped by NPM1-low versus NPM1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPM1→partner) and Y-score (partner→NPM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EEF1A1P39 →	+0.310	+4.324	.001	.007	3	2
LUAD	RN7SL557P →	+0.247	+6.693	<.001	<.001	3	2
SKCM	CSN1S2AP →	+0.381	+3.655	.001	.001	3	2
SKCM	RPS15AP27 →	+0.093	+3.099	.004	.007	3	2
UCEC	CCL27 →	+0.037	+4.148	<.001	.006	3	2
UCEC	RN7SKP181 →	+0.124	+3.133	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 295 associations by consensus.

EEF1A1P39 by NPM1 expression — COAD

Explore this box plot interactively →