NPM1

Across TCGA patient cohorts, NPM1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPM1-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, p38-MAPK, and TSC1. Each is linked with NPM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPM1-to-partner and partner-to-NPM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by NPM1-low versus NPM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPM1→partner) and Y-score (partner→NPM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.617	+3.000	.036	.037	3	1
UCEC	p38-MAPK →	-0.233	-3.000	.014	.037	3	1
UCEC	TSC1 →	-0.286	-3.000	.003	.037	2	1
UCEC	FoxM1 →	+0.348	+3.000	.020	.037	1	1
UCEC	STAT3_pY705 →	-0.612	-3.000	<.001	.037	1	1
UCEC	TFRC →	+0.842	+3.000	.005	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Acetyl-a-Tubulin-Lys40 by NPM1 expression — UCEC

Explore this box plot interactively →