NPM1

Across TCGA cell cohorts, NPM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,024 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible NPM1-associated GO terms across cancer lineages are Maturation of SSU-rRNA, Positive regulation of rRNA processing, and DNA replication initiation. Each is linked with NPM1 in more than 17 cancer types. Because this analysis shows association rather than direction, both NPM1-to-partner and partner-to-NPM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maturation of SSU-rRNA grouped by NPM1-low versus NPM1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NPM1→partner) and Y-score (partner→NPM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Maturation of SSU-rRNA →	+0.136	+0.813	.001	.004	3	18
UPPER_AERODIGESTIVE_TRACT	Positive regulation of rRNA processing →	+0.138	+1.164	<.001	<.001	3	17
PANCREAS	DNA replication initiation →	+0.165	+0.923	<.001	<.001	3	16
OVARY	rRNA processing →	+0.093	+0.809	<.001	.001	3	16
PANCREAS	Sister chromatid cohesion →	+0.094	+1.151	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	RNA 5'-end processing →	+0.092	+1.034	.001	.001	2	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,024 associations by consensus.

Maturation of SSU-rRNA by NPM1 expression — BONE

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