NPLOC4

Across TCGA patient cohorts, NPLOC4 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPLOC4-associated genes across cancer lineages are ERK2, mTOR_pS2448, and Akt_pT308. Each is linked with NPLOC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPLOC4-to-partner and partner-to-NPLOC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by NPLOC4-low versus NPLOC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPLOC4→partner) and Y-score (partner→NPLOC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.215	+2.700	.002	.005	3	2
UCEC	mTOR_pS2448 →	-0.128	-2.095	.019	.017	3	2
UCEC	Akt_pT308 →	+0.478	+2.000	.038	.029	3	2
UCEC	PDCD4 →	-0.506	-1.502	.003	.030	3	2
UCEC	C-Raf →	+0.129	+2.000	.014	.030	3	2
UCEC	EGFR_pY1068 →	-0.280	-1.847	.002	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

ERK2 by NPLOC4 expression — UCEC

Explore this box plot interactively →