NPIPB8

Across TCGA cell cohorts, NPIPB8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,191 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NPIPB8-associated GO terms across cancer lineages are Positive regulation of intracellular steroid hormone receptor signaling pathway, mRNA splice site recognition, and Negative regulation of mRNA splicing, via spliceosome. Each is linked with NPIPB8 in more than 12 cancer types. Because this analysis shows association rather than direction, both NPIPB8-to-partner and partner-to-NPIPB8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intracellular steroid hormone receptor signaling pathway grouped by NPIPB8-low versus NPIPB8-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NPIPB8→partner) and Y-score (partner→NPIPB8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.151	+0.650	<.001	<.001	3	13
URINARY_TRACT	mRNA splice site recognition →	+0.129	+0.464	.001	<.001	3	12
BLOOD_Lymphoma	Negative regulation of mRNA splicing, via spliceosome →	+0.114	+0.374	<.001	<.001	3	12
BLOOD_Lymphoma	Negative regulation of mRNA processing →	+0.108	+0.363	<.001	<.001	3	12
URINARY_TRACT	Cilium or flagellum-dependent cell motility →	-0.096	-0.430	<.001	.001	2	12
UPPER_AERODIGESTIVE_TRACT	mRNA 5'-splice site recognition →	+0.109	+0.534	.005	.005	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,191 associations by consensus.

Positive regulation of intracellular steroid hormone receptor signaling pathway by NPIPB8 expression — UPPER_AERODIGESTIVE_TRACT

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