NPIPB7

Across TCGA patient cohorts, NPIPB7 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,043 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible NPIPB7-associated GO terms across cancer lineages are Macromolecule methylation, Positive regulation of double-strand break repair, and Positive regulation of DNA metabolic process. Each is linked with NPIPB7 in more than 24 cancer types. Because this analysis shows association rather than direction, both NPIPB7-to-partner and partner-to-NPIPB7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Macromolecule methylation grouped by NPIPB7-low versus NPIPB7-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NPIPB7→partner) and Y-score (partner→NPIPB7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Macromolecule methylation →	+0.061	+0.132	<.001	<.001	3	25
ESCA	Positive regulation of double-strand break repair →	+0.065	+0.163	<.001	<.001	3	25
ESCA	Positive regulation of DNA metabolic process →	+0.066	+0.142	.001	<.001	3	24
ESCA	Regulation of DNA repair →	+0.039	+0.078	.001	<.001	3	24
ESCA	tRNA metabolic process →	+0.038	+0.099	<.001	<.001	3	24
ESCA	tRNA modification →	+0.036	+0.100	<.001	<.001	3	24

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,043 associations by consensus.

Macromolecule methylation by NPIPB7 expression — ESCA

Explore this box plot interactively →